The perturbation of a membrane model due to the presence of different structures that form nanopores in lipid bilayers is studied in detail. Specifically, a Carbon Nanotube (CNT), a pore protein minimalist model and three channels based on the self-assembly of cyclic peptides embedded in DOPC bilayers were studied by computational molecular dynamics simulations. The original analysis performed on the resulting trajectories reveals specific undulation patterns with periodic spatial distributions of several structural and dynamic properties as a function of the distance to the nanopores that are highly sensitive to the macromolecule embedded in the membrane model. This work provides new insight on how membranes may adapt themselves to host different macromolecular structures.

Nanopore inserted into a membrane

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